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pentobarbital will minimize the extent or influence of pimozide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Unfamiliar.pentobarbital will lower the level or result of celecoxib by affecting hepatic enzyme CYP2C9/10 metabolism. Slight/Significance Unidentified.pentobarbital will lower the extent or impact of tofaciti